Recent advances have highlighted the outstanding role of the innate immune system for instructing adaptive immunity. Translating this knowledge into successful immunotherapies like vaccines, however, has proven to be a difficult task. This essay is based on the hypothesis that immune responses are tightly scaled to the infectious threat posed by a given microbial stimulus. A meticulous immunological risk‐assessment process is therefore instrumental for eliciting well‐balanced responses and maintaining immune homeostasis. The immune system makes fine distinctions, for example, between live (...) and dead bacteria, or pathogenic and non‐pathogenic microorganisms. Here, I discuss recent evidence for some of the mechanisms underlying these distinctions and speculate on strategies for therapeutically targeting the immunological risk‐assessment machinery. (shrink)

The long-awaited revision of the industry standard on phylogenetics Since the publication of the first edition of this landmark volume more than twenty-five years ago, phylogenetic systematics has taken its place as the dominant paradigm of systematic biology. It has profoundly influenced the way scientists study evolution, and has seen many theoretical and technical advances as the field has continued to grow. It goes almost without saying that the next twenty-five years of phylogenetic research will prove as fascinating as the (...) first, with many exciting developments yet to come. This new edition of Phylogenetics captures the very essence of this rapidly evolving discipline. Written for the practicing systematist and phylogeneticist, it addresses both the philosophical and technical issues of the field, as well as surveys general practices in taxonomy. Major sections of the book deal with the nature of species and higher taxa, homology and characters, trees and tree graphs, and biogeography—the purpose being to develop biologically relevant species, character, tree, and biogeographic concepts that can be applied fruitfully to phylogenetics. The book then turns its focus to phylogenetic trees, including an in-depth guide to tree-building algorithms. Additional coverage includes: Parsimony and parsimony analysis Parametric phylogenetics including maximum likelihood and Bayesian approaches Phylogenetic classification Critiques of evolutionary taxonomy, phenetics, and transformed cladistics Specimen selection, field collecting, and curating Systematic publication and the rules of nomenclature Providing a thorough synthesis of the field, this important update to Phylogenetics is essential for students and researchers in the areas of evolutionary biology, molecular evolution, genetics and evolutionary genetics, paleontology, physical anthropology, and zoology. (shrink)

The vexed question of the exact significance of the name of Mavortius in the old Putean MS. of Prudentius has again been called into court in the recent discussions of the Mavortian recension of Horace, and is fully treated in Dr. Bick's Horazkritik seit 1880, pp. 31–35. As Dr. Bick has done me the honour of subjecting my former articles on the question to his criticism, I feel called upon to say something in defence of the view I maintained. I (...) willingly grant him that perhaps I laid too strong a stress on the connection of the question with Horatian criticism; but I do so, I fear, not as a convert to his arguments in favour of the view that Put. is merely a copy of a MS. that had Mavortius' autograph written in it, and that therefore that name is part of a lost subscriptio, but precisely for the contrary reason, that I consider I was too much influenced by former advocates of that view. That there is no ground for assuming the name to be part of a lost subscriptio I am more than ever convinced, and my object here is to endeavour to show that the whole argument based on a false premise. (shrink)

This is an authentic record of an unauthentic paper.

BackgroundKinarm Standard Tests is a suite of upper limb tasks to assess sensory, motor, and cognitive functions, which produces granular performance data that reflect spatial and temporal aspects of behavior. We have previously used principal component analysis to reduce the dimensionality of multivariate data using the Kinarm End-Point Lab. Here, we performed PCA using data from the Kinarm Exoskeleton Lab, and determined agreement of PCA results across EP and EXO platforms in healthy participants. We additionally examined whether further dimensionality reduction (...) was possible by using PCA across behavioral tasks.MethodsHealthy participants were assessed using the Kinarm EXO and EP. Four behavioral tasks were performed that quantified arm sensory and motor function, including position sense [Arm Position Matching ] and three motor tasks [Visually Guided Reaching, Object Hit, and Object Hit and Avoid ]. The number of components to include per task was determined from scree plots and parallel analysis, and rotation type was decided on a per-task basis. To assess agreement, we compared principal components across platforms using distance correlation. We additionally considered inter-task interactions in EXO data by performing PCA across all six behavioral assessments.ResultsBy applying PCA on a per task basis to data collected using the EXO, the number of behavioral parameters were substantially reduced by 58–75% while accounting for 76–87% of the variance. These results compared well to the EP analysis, and we found good-to-excellent agreement values between PCs from the EXO and those from the EP. Finally, we were able to reduce the dimensionality of the EXO data across tasks down to 16 components out of a total of 76 behavioral parameters, which represents a reduction of 79% while accounting for 73% of the total variance.ConclusionPCA of Kinarm robotic assessment appears to capture similar relationships between kinematic features in healthy individuals and is agnostic to the robotic platform used for collection. Further work is needed to investigate the use of PCA-based data reduction for the characterization of neurological deficits in clinical populations. (shrink)

One of the central issue of developmental biology concerns the molecular mechanisms whereby a multipotent cell gives rise to distinct differentiated progeny. Differences between specialised cell types reflect variations in their patterns of gene expression. The regulation of transcription initiation is an important control point for gene expression and it is, therefore, not surprising that transcription factors play a pivotal role in mammalian development and differentiation.Haemopoiesis offers a uniquely tractable system for the study of lineage commitment and differentiation. The importance (...) of transcription factor in the normal regulation of haemopoiesis is underlined by the frequency with which transcription factors are targeted by leukaemogenic mutations. Studies of the function and regulation of haemopoietic transcription factors, especially those expressed in lineage‐restricted patterns, should greatly increase our understanding of the molecular control of haemopoiesis. In this review we have focused on insights provided by recent studies of the GATA and SCL proteins. (shrink)

DEATH is one of the central themes of existentialist writing. This is to be expected since the focal point of all its reflection is human existence. Existentialism explores the innermost depths of experienced selfhood. Inevitably, the authentic self must face the problem of man’s origin and destiny or, in Heideggerian terms, the beginning and ending of his Being-in-the-world. Death is a profoundly human problem, inseparably bound up with the psychological and ontological structure of the human mode of being or Dasein.

Книга посвящена рассмотрению ряда актуальных проблем современной эпистемологии, особое внимание уделяется новым подходам к классическим вопросам теории познания. Авторы предлагают свой анализ таких проблем.

The author tries to prove that hypnosis is a science to be used in everyday life. Hence his efforts to locate the lost body of a dead woman through hypnosis and the help of a very sensitive medium. The initial practical point of learning the whereabouts of the body gets lost however—the body is never found-in the course of his dialogues with the patient through whom he has contacted a "privileged soul" who lives close to the "Leader" in the highest (...) hierarchy of heaven. Mr. Ward attempts to provide simple answers to the great questions of life and death in an authoritative manner. Most of the book is in question and answer form with a final chapter of summary and conclusions. Altogether it is a naive exposition of a much disputed field.—E. O. T. (shrink)

Written by a prominent figure in Arab politics today and a well-known Islamic scholar, the book, after one chapter on the life of the Prophet, concentrates on an exposition of the essential message of Islam that purports to show its relevance to our contemporary world. Its pages abound in examples of religious toleration among the followers of Islam in the past to show how misled Westerners have been in depicting a religion of "righteousness" and "brotherhood" as the religion of the (...) sword.—E. O. T. (shrink)

I venture to call the attention of classical scholars to two legends about Roman Emperors gleaned amid the arid waste of theological nonsense which passed for literature among the Copts, in the hope that they may have better luck than I have had in tracing them to some classical source. The first is taken from MS. Par. Copte 131, fol. 40, a single leaf of what seems to be a geographical and historical encyclopaedia.1 The writer who is treating in a (...) very discursive way of Ethiopia, states that Nero or Domitian—a strange pair to run in double harness—caused an island in the Red Sea to be watered with oil. The description of that island is mixed up with a mention of the original divisions of the Indians—a term which as usual in early days embraces both Indians and Ethiopians,—and their subsequent changes; and as that too may be of interest to students of ancient geography, I will translate the passage in full. (shrink)